What is Brugada Syndrome?

In Brugada Syndrome the underlying fault may be due to changes within the cells of the heart (ion channels). Ion channels alter the chemical balance of the cardiac cells, by adjusting the amount of electrical charge to them, therefore if the electrical properties of the cell are faulty this can result in a disturbance of the heart rhythm (arrhythmia). In Brugada syndrome the ion affected is the sodium channel. Brugada syndrome is referred to as a channelopathy, this is the term given to conditions where there are changes in genes that determine the ion channels. Your heart is otherwise structurally normal.

In some cases, genes have been identified for Brugada syndrome however, the list identified is not complete. It is therefore not possible to be absolutely sure that a patient has not got Brugada even if genetic screening is negative. Please remember that if you are advised to have genetic screening it may take some time to perform.

In Brugada Syndrome some patients may be at risk of developing fast heart rhythms, which may result in blackout or very rarely sudden death. If the ventricles start beating at an abnormally fast rate this results in the heart not working as efficiently, which can cause symptoms of weakness, dizziness, chest pain, shortness of breath or even collapse. However, it is important that you remember that the majority of patients who have Brugada do not experience arrhythmias and feel perfectly well.

It is very important that if you have a close family member diagnosed with the condition or who dies young that all remaining relatives are screened for Brugada Syndrome. Your doctor suspects that you may have Brugada syndrome and he has advised you to have a simple test known as a Flecainde Challenge to confirm the diagnosis.


Why do I need a Flecainide Challenge?

Your doctor has advised you to undergo a flecainide challenge to exclude Brugada syndrome. Flecainide challenge is a well-established clinical test. It is undertaken to see if you have a hidden form of Brugada syndrome. The purpose of the test is to use a drug called Flecainide to uncover the characteristic ECG changes of the syndrome. The characteristic ECG pattern of Brugada Syndrome is shown below.



What is a Flecainide?

Flecainide is a drug known as a Sodium Channel Blocker. It is routinely used by doctors to prevent abnormal heart rhythms these drug are called antiarrhythmics. Flecainide is used by doctors in this test as it blocks the faulty sodium channels and unmasks ECG changes in those patients who have Brugada. In patients with normal cardiac cells flecainide has little or no effect on the ECG.

Your doctor will administer the drug through a vein in your arm and record your ECG every three minutes; ECG’s record the electrical signals (activity) from inside your heart. The ECG will record how your heart reacts to Flecainide, this allows your doctor to collect detailed information about the cause of your potential arrhythmia. The Flecainide challenge is undertaken in a ward setting with cardiac monitoring. Children are taken to the intensive care area for monitoring during the test.

Is the Flecainide Challenge safe?

Yes, the flecainide challenge is safe. However, as with any procedure, there are potential risks. The risks are outlined below and will be fully explained by our doctors before you have your procedure. The Flecainide challenge is performed safely in both children and adults.

In our experience complications associated with this procedure are very rare. It is important that you are aware that on rare occasions there are some risks associated with this procedure that may occur either during, or after the procedure. These risks as outlined below can be treated and are rarely life threatening.


What to Expect During the Test?

Before Admission

If you are taking medication you generally do not need to stop taking it. Please let us know what medications you are taking.


Before the Flecainide Challenge

On your arrival to the ward you will be introduced to the nurse who will be looking after you. The nurse will talk to you and your family about your hospital admission and answer any questions you may have. Before the procedure you will have a baseline electrocardiogram (ECG) recorded. A doctor will also see you and explain the procedure to you, he will then ask you to sign a consent form; this is to ensure you understand the ablation procedure and its associated risks. If you have any worries or questions please do not be afraid to ask. It is important to tell your nurse or doctor if you have any allergies or have had a previous reaction to drugs or other tests.

Before the procedure a nurse will help to get you ready. The doctor or nurse will need to insert a small needle into a vein in your hand (cannula) this is to allow the doctor to give you the Flecainide during the procedure. You will then be given a hospital gown to wear, this allows us to record the ECG easily.


During the Flecainide Challenge

It is unlikely that you will experience any adverse sensations at all during the test. Although you may feel very anxious during the procedure, the staff involved in your care are very aware of your possible anxieties. Your doctor and nurse will stay with you and be there to reassure you throughout the test. There will be equipment by your bedside, this is used to monitor your heart rhythm and record your blood pressure. You will be awake during the test and able to talk to us.

The nurse or doctor will connect you to the flecainide infusion, this may sting a little and you may feel some mild discomfort. You will then be connected to the ECG machine. Once the infusion is running your doctor will record the ECG at three-minute intervals for the duration of the test. You should not feel anything. However, sometimes patients do complain of a metallic taste in mouth, numbness around the lips or blurred vision these side effects usually resolve quickly once the test is completed. If you do have any uncomfortable symptoms during the test for example, chest pain, dizziness, shortness of breath, please tell your nurse or doctor. Do not be alarmed that the doctor is looking closely at the ECG during the test, it does not mean there is anything wrong. The doctor must look closely at your ECG to note changes.


What do patients commonly experience?
It is common to experience a metallic taste in your mouth during the administration of the Flecainide. Again, you may experience visual disturbance such as double vision. Such side effects usually resolve quickly once the infusion is completed. Very rarely, in less than 1% of patients the Flecainide may cause your heart to go into a very fast ventricular rhythm, if this happens the doctor will need to correct your arrhythmia quickly by cardioversion. Cardioversion is a treatment for heart rhythms that are irregular. Before you are cardioverted you will be given a short-acting sedative to make you sleepy. Once you are asleep a special machine called a defibrillator is used to send electrical energy to the heart muscle to restore the normal rhythm and rate.

After the doctor has performed the test, you will be kept in the monitored bed and continue to be monitored for approximately one hour after the procedure. After this time you will then be moved to the ward area.

There is a very low risk that you may experience an arrhythmia or develop ECG changes of Brugada after the Flecainide has been administered and hence we monitor your heart rhythm for several hours after the drug has been given, even if the test is negative.  If the test is positive we will admit you to hospital overnight and monitor your heart rhythm but you will be able to go home the following day.

After the Procedure
After the procedure you will be monitored for 6 hours. The IV line will then be removed after this time. You will be able to eat and drink. The nurse will check your blood pressure, pulse. The nurse will remove the small needle in your hand. If you feel any palpitations or dizziness after the test, please let the nurse know.

The doctor will show your ECG’s to your Consultant Cardiologist. Your doctor will then discuss the findings of the test with you and your family.

When will I know the result of my procedure?
After your test your doctor will discuss the ECG recordings with your consultant. The doctor will then discuss results and ongoing treatment plan with you and your family.

What treatment options are available for me?
If the test is negative, you may not require any treatment at all, or you may be advised to undergo further tests. If the test is positive, you may be advised to undergo further tests. Your Consultant will discuss the risks and benefits with you on an individual basis.

Your Discharge
You will normally be able to go home that day if the test is negative. If the test is positive you will be admitted overnight to monitor your heart rhythm and then be discharged in the morning. It is important to ask a family member or friend to collect you and drive you home.

When can I resume my normal activities?
You can resume your normal daily activities (walking, bathing, showering, etc.) and return to work upon discharge from hospital.

Will I come back here for follow-up?
Upon discharge from the hospital, you will receive specific follow-up instructions by our nurses. Our doctors will write a detailed letter to your GP describing your hospital stay and treatment.


Our Research

Melbourne Heart Rhythm has an international reputation as one of the centers of excellence in cardiac arrhythmia research in Australasia and the world.

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Our Team

Our friendly team are committed to providing excellence in patient care. They are all well qualified and knowledgeable about patients and their cardiac conditions.

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To learn about common arrhythmias and our cardiac procedures, visit  our Cardiovascular Library for more information.

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About Us


Melbourne Heart Rhythm is the arrhythmia service at the Department of Cardiology at the Royal Melbourne Hospital. We are comprised of a team of highly trained and dedicated health care professionals specializing in heart rhythm management. We have a strong focus on patient education and patient centered care. Our arrhythmia specialists have an international reputation of excellence in arrhythmia research and clinical arrhythmia management.